Product Focus

Three new products available for trainers this spring 2023

PAVESCO - TWYDIL® ARTRIDAY

NEW feed supplement for joints from TWYDIL®, Switzerland.

Since MSM has been registered as a controlled substance, we decided to launch on the equine market a product that can be used daily and long term.

Following our recent scientific investigations, it appears that the combination of chondroïtin, glucosamine, pro-anthocyanin and ASU brings an active and efficient support on the cartilage health and its functionality. 

ASU means « avocado and soybean unsaponifiable fatty acids ». This extract is particularly efficient for the stabilisation of the cartilage extra-cellular matrix, bringing a noticeable preventive effect. The combination of these ingredients have an effect on all parts of the joints: cartilage, synovial fluid and membrane. The pro-anthocyanin fraction has a powerful anti-oxidant property with a high tropism for joints, so breaking the vicious circle conducting to lameness.

Horses show an improvement of their general suppleness and of their stride. The well-being is also taken into consideration because training is better tolerated. 

50g daily for 30 days minimum is recommended to observe an improvement. It may be needed to continue for a longer period in sensitive horses.

The product is available in 1.5 kg pails.

For more information visit: www.twydil.com

NAF Five Star Metazone 

By Dr Andy Richardson BVSc CertAVP(ESM) MRCVS, Veterinary Director at NAF

Whatever the challenge, keep your yard ‘in the zone’ with NEW NAF Five Star Metazone. 

Metazone has been formulated by the Veterinary and Nutrition experts at NAF and is an innovative, evidence based nutraceutical that targets the support of natural anti-inflammatory pathways in all racehorses. The synergistic blend of plant based phytochemicals that make up this product support these pathways wherever they are needed in the body - whether that be for joints, hooves, tendons, ligaments, muscles or skin. The unique herbal complex of Metazone works in synergy wherever those triggers occur within the system, to ensure we maintain freedom from discomfort. Maintaining optimum comfort ensures racehorse welfare and provides an optimal environment for recovery and maximising athletic potential.

Unwanted or excessive inflammation is a major issue for the well-being and performance of horses in training and a major cause of lost training days and missed races. Metazone is the culmination of many years of research and knowledge gathered by the scientific team at NAF on how plant based phytochemicals can positively influence the body.

Formulated specifically to manage, relieve and control, Metazone provides nutritional support for common issues that may interrupt a training schedule. Metazone supports a horse’s natural anti-inflammatory responses, which are often under maximum stress when in training, helping them to stay sound through periods of repeated, strenuous exercise. The product is suitable when a short term boost is needed but may also be used for long term daily administration when comfort is key. The natural formula is gut kind and designed to work effectively without compromising gut health. It can be fed alongside any other NAF product that will support underlying structures as required.

Independently trialled, Metazone has been robustly trialled by equine researchers at The Royal Agricultural University, Cirencester in a blinded, cross-over designed trial, and assessed by a panel of external vets. Real results research also includes trials with leading trainers, who have all seen the benefit of getting their horses ‘in the Metazone’. 

Metazone is available as a fast-acting liquid, in an instant use syringe and as palatable powder. The liquid comes in 5L and 1L sizes with the syringes available as 3 x 30ml and the powder is in a 1.2kg tub. 

For more information on pricing and the product, contact NAF’s Racing Manager Sammy Martin on 07980 922041 or smartin@naf-uk.com. 

Plusvital - Neutragast

Plusvital Neutragast is now available in pellets.

Ideal for fussy eaters, Neutragast Pellets promote gastrointestinal health in convenient & palatable soy protein base pellet form.

Using research proven ingredients to promote digestive performance the pellets contain key ingredients boswellia extract, calcified seaweed, saccharomyces cerevisiae and provides a source of B vitamins to help with food metabolism.

Boswellia extract (Terepenes and Boswellic acids) have been shown to have several beneficial effects including anti-inflammatory and analgesic properties. Boswellia compounds have been shown to be of benefit in cases of intestinal inflammation. This is achieved through modulation of the inflammatory cell (leukocyte) response.

Calcified seaweed has been reported to have a positive effect on buffering of pH in equine stomachs. Presented in the form of Lithothamnium Calcareum this acts as a safeguard against excess acid within the stomach.

Additionally Plusvital Neutragast Pellets contain the amino acid Threonine which is one of the main amino acid components of the protein mucin. Mucin forms a gel-like structure which makes up the mucosal barrier that protects the stomach wall against its own acidic secretions.

Saccharomyces cerevisiae (active yeast) is a probiotic which promotes intestinal health through multiple pathways including increased fibre digestion.

As it is a pellet supplement it works well with pelleted feed or straight feed concentrates and can be used as part of a daily routine.

For more information visit: www.plusvital.com

Probiotics as an alternative to antibiotics to reduce resistance in the gut

Article by Kerrie Kavanagh

The leading causes of horse mortality can be attributed to gastrointestinal diseases. Therefore, maintaining the balance of the gut microbiota and avoiding a shift in microbial populations can contribute to improved health status. The gut microbiota, however, can be influenced by countless dynamic events: diet, exercise, stress, illness, helminth infections, aging, environment and notably, antimicrobial therapy (antibiotics). These events can lead to gut dysbiosis—a fluctuation or disturbance in the population of microorganisms of the gut, which can contribute to a wide range of disease. The use of antibiotics in horses is thought to have one of the most notable effects on the gut microbiota (gut dysbiosis), which can lead to diseases such as colitis, colic and laminitis.

Antibiotics, which are antimicrobial agents active against bacteria, are important to equine medicine; and bacterial infections can be resolved quite successfully using antibiotics for antimicrobial therapy, but there are consequences to their use. An antimicrobial agent can be defined as a natural or synthetic substance that kills or inhibits the growth of microorganisms such as bacteria, fungi and algae. One of the consequences of antibiotic use is that of antibiotic-associated diarrhoea, which can contribute to poor performance in the horse and even mortality. In antimicrobial therapy, the target organism is not the only organism affected by the antimicrobial agent but also the commensal microbiota too (the normal flora of the equine gut). Antibiotics can promote fungal infections and resistant organisms and impede or even eliminate the more sensitive organisms; and they can have both short and long-term consequences on the gut microbiota composition and function. 

Research has indicated that antibiotic treatment may adversely affect metabolic function in the gut by decreasing protein expression responsible for biochemical pathways such as glycolysis, iron uptake, glutamate hydrolysis and possibly even more metabolic functions. The use of antimicrobial drugs directly impacts and possibly contributes to the most notable effect on the gut microbiota of the host, leading to gut dysbiosis; and certain antibiotics can have further-reaching consequences on the microbiota than others. The type of antibiotic and mode of action (bacteriostatic versus bactericidal) will differ in their influences on the gut microbiota composition, e.g., clindamycin operates a bacteriostatic mode of action by inhibiting protein synthesis and exerts a larger impact on the gut microbiota compared to other antimicrobials. These influential consequences that are imparted by the antimicrobial agent are relatively yet to be elucidated and may result in the manifestation of illness or conditions later in life. For example, the development of asthma in humans has been linked to antibiotic treatment in early childhood as a result of bacterial infections. It may yield interesting results if researchers were to examine the gut microbiome of horses suffering from chronic obstructive pulmonary disease (COPD) and other chronic respiratory illnesses and to establish if there is indeed a link with antibiotic therapy used in horses from an early age. 

In comparison to the vast wealth of human studies conducted so far, the volume of equine studies falls disappointingly far behind, but that is changing as researchers focus their interest on developing and filling this gap of knowledge. One such study which examined the effect of antibiotic use on the equine gastrointestinal tract, demonstrated a significant reduction in culturable cellulolytic bacteria (>99%) from equine faeces during the administration period of trimethoprim sulfadiazine and ceftiofur in a study comparing responses to antibiotic challenge. That reduction was still evident at the end of the withdrawal period when compared to the control group. In other words, there was a significant reduction in the ‘normal’ bacteria of the gut. The ability of antibiotics to modulate the gut microbiota was evidenced by the proliferation of pathogenic Salmonella and Clostridia difficile (commonly associated with diarrhoea in horses) in the antibiotic challenged horses. This trend of reduction in cellulolytic bacteria associated with antibiotic use was also mirrored in a relatively recent study conducted in 2019, where a short-term reduction in culturable cellulolytic bacteria was combined with a progressive increase in amylolytic bacteria. The heavy reliance on cellulolytic bacteria in the role of equine digestion (without these types of bacteria the horse cannot break down their food) may, therefore, adversely affect the dietary energy available from forage during antimicrobial therapy and may therefore impact performance.

Another study that compared the effect of penicillin, ceftiofur and trimethoprim sulfadiazine (TMS) on the gut microbiota in horses using next-generation sequencing showed that TMS had the most profound impact on the microbiota, in particular the phylum Verrucomicrobia. This same study also reported a significant decrease in bacterial richness and diversity of the faecal microbiota. A reduction in bacterial diversity is certainly a trend that is commonly seen in gastrointestinal disease in horses. The restoration of the normal gut microbiota after completion of antibiotic treatment can take up to 40 days, but the organisational structure of the bacterial populations can take many years to re-establish the original structure map that was laid out in the gut pre-antibiotic treatment. 

The equine studies certainly show similarities to the human studies, indicating the consequences of antibiotics that can be seen across more than one species. Human studies have reported long-term consequences of antibiotic treatment on the human microbiota. One such human study investigated a 7-day clindamycin treatment and monitored the patients for two years. The impact on the human microbiota remained evident two years post-treatment, where a reduction in bacterial diversity and detection of high-resistance to clindamycin were detected. 

Interestingly, no resistant clones were detected in the control group over the two-year sampling period. Another study focusing on the effects of antibiotic treatment for Helicobacter pylori showed findings mirrored in similar studies of that field. The findings demonstrated the rapidly reducing bacterial diversity (one week) after antibiotic treatment and found that disturbances in the microbiota and high levels of macrolide resistance were evident four years post-treatment. Human studies may predict that equine studies will find similar trends with equine antimicrobial therapy. These studies highlight the impact of antibiotic use and the long-term persistence of antibiotic resistance remaining in the intestinal microbiome, which is a concern for both humans and animals. 

Antibiotics can lead to the selectivity and proliferation of resistant bacteria, which is evidenced by the long-term effects observed on the gut microbiota harbouring drug-resistant encoded genes. Horizontal gene transfer (HGT) commonly occurs in the gut (can be up to 25 times more likely to occur in the gut than in other environments). HGT can be attributed to the close proximity of the microbiota in the gut, allowing the transfer of genetic material via routes such as plasmids and conjugation; in other words, the bacteria in the gut have developed a pathway to transfer antibiotic resistant genes from one generation to another. Resistance to antibiotics is now a global issue for the treatment of many diseases. 

With the unfavourable association tied to Clostridium difficile infections (CDI) and the onset of colitis particularly in mature horses treated with β-lactam antibiotics (commonly used for equine infections), the incidences in which antimicrobial therapy is considered should be minimised and only used if entirely necessary. The use of broad-spectrum antibiotics in recurrent presentations of symptoms of disease such as urinary tract infections in humans or diarrhoea as a result of CDI in both humans and horses is promoting drug resistance.

The antibiotics, by disrupting the gut microbiota (which act as a defence against the establishment and proliferation of such pathogenic bacteria) are allowing the opportunity of growth for these multi-resistant microorganisms such as C. difficile, vancomycin-resistant enterococci (VRE), and multi-resistant Staphylococcus aureus (MRSA). The organism C. difficile and its antibiotic resistance has been demonstrated in the treatment of CDI for both humans and animals. The introduction of vancomycin (a glycopeptide antibiotic) in 1959 for the control of CDI remained effective until the 1990s when a more virulent form of C. difficile emerged. This new form of C. difficile with reported broad-spectrum antibiotic resistance resulted in chronic conditions and increased human mortality. C. difficile is most noted with human hospital-acquired infections. C. difficile BI/NAP1/027 has been shown to have resistance to fluoroquinolone antibiotics, moxifloxacin and gatifloxacin, which was not seen in historical genotypes. As C. difficile infections are found to cause gastrointestinal disease in horses as well as humans, this is certainly of concern.

Alternative therapies to antibiotic therapy to restore or modulate the gut microbiome after a gut dysbiosis event could be considered in certain circumstances where antibiotics are no longer effective (e.g., CDI), nor may they not be the best course (presence of Extended-spectrum -β-lactamase producing (ESBL) organisms) nor essential for example, when the diagnosis of the bacterial cause is uncertain. The rationale to using probiotic treatment along with antimicrobial treatment is that the antibiotic will target the pathogenic bacteria (e.g., C. difficile) and also the commensal microbiota of the gut, but the probiotic bacteria will help to re-establish the intestinal microbiota and in-turn prevent the re-growth of the pathogenic bacteria in the case or residual spores of C. difficile surviving the antibiotic treatment. Alternative therapies such as faecal microbiome transplant (FMT) or probiotic solutions can reduce the risk of proliferation of antibiotic-resistant bacteria and also have fewer implications on the gut microbiome as evidenced by antibiotic use. 

Probiotics have been defined by the Food and Agricultural Organisation (FAO) and the World Health Organisation (WHO) as “live non-pathogenic microorganisms that, when administered in adequate amounts, confer a health benefit on the host”. The word ‘probiotic’ is Greek in origin, meaning, ‘for life’; and the term was coined by Ferdinand Vergin in 1954. While the mechanisms of action of probiotics are complex and require a deeper knowledge of the modulations of the gastrointestinal microbiota, and the health benefits due to their use are the subject of some debate, there is no doubt that probiotics are considered by many as a vital resource to human and animal health.   

The use of probiotics in animal production, particularly in intensive swine and poultry production, has increased in recent years, primarily as an alternative to the use of antimicrobials in the prevention of disease. The problem of antibiotic-resistance and antimicrobial residues in food-producing animals (the horse is considered a food-producing animal), as a result of historical antibiotic use with the corresponding reduction in antibiotic efficacy in humans, leads to having to look at more sustainable options such as probiotic use to combat disease. Probiotics in horses are predominantly used as a treatment modality in the gastrointestinal microbial populations to combat illnesses such as diarrhoea—to prevent diarrhoea (particularly in foals) or help improve digestibility.  Shifts or fluctuations in the microbial populations of the equine gastrointestinal tract have been associated with diseases such as laminitis and colic.  

Gut dysbiosis, as mentioned previously is, a fluctuation or disturbance in the population of microorganisms of the gut is now being recognised as a cause of a wide range of gastrointestinal diseases; and in horses, it is one of the leading causes of mortality. The ability of probiotics in conferring health benefits to the host can occur via several different mechanisms: 1) inhibiting pathogen colonisation in the gut by producing antimicrobial metabolites or by competitive exclusion by adhering to the intestinal mucosa preventing pathogenic bacteria attachment by improving the function and structure; 2) protecting or restabilising the commensal gut microbiota; 3) protecting the intestinal epithelial barrier; 4) by inducing an immune response.

It is known that there is a wealth of factors that will adversely affect the gut microbiome, antibiotics, disease, diet, stress, age and environment are some of these compounding contributors. To mirror one researcher’s words echoing from an era where antibiotics were used as growth promoters in the animal industry, “The use of probiotic supplements seeks to repair these deficiencies. It is, therefore, not creating anything that would not be present under natural conditions, but it is merely restoring the flora to its full protective capacity”. In the case of using concurrent antibiotic and probiotic treatment, this strategic tweaking of the microbiota could be used as a tool to prevent further disease consequence and perhaps help improve performance in the horse.

The benefits of probiotic use in horses have not been investigated extensively but as mentioned previously, they are now being focused upon by researchers in the equine field. The most common bacterial strains used in equine probiotic products are Lactobacillus, Bifidobacterium, Streptococcus, Enterococcus, Bacillus and yeast strains of Saccharomyces. Lactobacillus, Bifidobacterium and Enterococcus strains typically account for less than 1% of the microbiota large gastrointestinal populations.

Regulation is lacking regarding labelling of probiotic products, often not displaying content with clarification and quality control (such as confirmed viability of strain[s]) not excised with over-the-counter probiotic products. There is evidence to suggest that host-adapted strains of bacteria and fungi enjoy a fitness advantage in the gut of humans and animals.  Therefore, there may be an advantage in using the individual animal’s own bacteria as potential probiotics. Probiotics and antibiotics used concurrently could be the way to minimise the introduction of antibiotic-resistant bacterial strains in the gut, and in turn, protect future antibiotic efficacy. 

The Balancing Act

By Catherine Rudenko

Key considerations when reviewing what you feed and if you should supplement

With so many feeds and supplements on the market, the feed room can soon take on the appearance of an alchemist’s cupboard. Feeding is of course an artform but one that should be based on sound science. In order to make an informed decision, there are some key questions to ask yourself and your supplier when choosing what ingredients will form your secret to success. 

Question #1: What is it? 

Get an overview of the products’ intended use and what category of horse they are most suited for. Not every horse in the yard will require supplementing. Whilst one could argue all horses would benefit from any supplement at some level, the real question is do they need it? Where there is a concern or clinical issue, a specific supplement is more likely warranted and is more likely to have an impact. A blanket approach for supplements is really only appropriate where the horses all have the same need (e.g., use of electrolytes).  

Question #2: Is it effective? 

There are many good reasons to use supplements with an ever-increasing body of research building as to how certain foods, plants or substances can influence both health and performance. Does the feed or supplement you are considering have any evidence in the form of scientific or clinical studies? Whilst the finished product may not—in a branded sense—be researched, the active components or ingredients should be. Ideally, we look for equine-specific research, but often other species are referenced, including humans; and this gives confidence that there is a sound line of thinking behind the use of such ingredients. 

Having established if there is evidence, the next important question is, does the feed or supplement deliver that ingredient at an effective level? For example, if research shows 10g of glucosamine to be effective in terms of absorption and reaching the joint, does your supplement or feed—when fed at the recommended rate—deliver that amount? 

There is of course the cocktail effect to consider, whereby mixing of multiple ingredients to target a problem can reduce the amount of each individual ingredient needed. This is where the product itself is ideally then tested to confirm that the cocktail is indeed effective. 

Question #3: How does it fit with my current feeding and supplement program? 

All too often a feed or supplement is considered in isolation which can lead to over-supplementing through duplication. Feeds and supplements can contain common materials, (i.e., on occasion there is no need to further supplement or that you can reduce the dose rate of a supplement). 

Before taking on any supplement, in addition to your current program, you first need to have a good understanding of what is currently being consumed on a per day basis. …

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