Can we use biomarkers to predict catastrophic racing injuries?
/By Holly Wiemers
University of Kentucky study shows association between mRNA biomarkers and catastrophic injuries in Thoroughbred racehorses— a positive step forward in the development of a pre-race screening tool.
Catastrophic injuries in Thoroughbred racehorses is a top-of-mind concern for the global racing industry and its fans. That sentiment is shared by researchers at the University of Kentucky and their collaborators, who are working to learn more about changes happening at a cellular level that might indicate an injury is lurking before it becomes career or life ending. Could it be possible to identify an early marker or signal in horses at risk of catastrophic injury, allowing for intervention before those injuries happen? And, if so, might this type of detection system be one that could be implemented cost effectively on a large scale?
According to Allen Page, DVM, PhD, staff scientist and veterinarian at UK’s Gluck Equine Research Center, the short answer to both questions is that it looks promising.
To date, attempts to identify useful biomarkers for early injury detection have been largely unsuccessful. However, the use of a different biomarker technology, which quantifies messenger RNA (mRNA), was able to identify 76% of horses at risk for a catastrophic injury. An abstract of this research was recently presented at the American Association of Equine Practitioners’ annual meeting in December 2020 and the full study published January 12 in the Equine Veterinary Journal (www.beva.onlinelibrary.wiley.com/journal/20423306).
In this initial research—which looked at 21 different mRNA markers selected for their roles in encoding proteins associated with inflammation, bone repair and remodeling, tissue repair and general response to injury— three markers showed a large difference in mRNA levels between injured and non-injured horses.
For almost four years, Page and his University of Kentucky colleagues have been analyzing blood samples from almost 700 Thoroughbred racehorses. These samples, collected by participating racing jurisdictions from across the United States, have come from both catastrophically injured and non-injured horses in a quest to better understand changes that might be happening at the mRNA level and if there are any red flags which consistently differentiate horses that suffer a catastrophic injury. …
CLICK HERE to return to issue contents or sign up below to read this article in full
BUY THIS ISSUE IN PRINT OR DOWNLOAD
ISSUE 60 (PRINT)
$6.95
ISSUE (DIGITAL)
$3.99
WHY NOT SUBSCRIBE?
DON'T MISS OUT AND SUBSCRIBE TO RECEIVE THE NEXT FOUR ISSUES!
Four issue subscription - ONLY $24.95